Tuesday, December 16. 2008in News
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Glioblastoma, a form of metastatic brain cancer with poor prognosis, has been highlighted again by Skog et. al. for the formation of Micorvesicles. These microvesicles, or exosomes, are secereted by the tumor into the serum and contain mRNA, miRNAs and certain proteins. The mRNAs encode different genes, one of which is an oncogenic form of the growth factor receptor, EGFR. Proteins contained within the vesicles also trigger tumor growth of glioblastomas, tubule formation in vascular endothelial cells and micro RNAs. These microvesicles are detectable in the serum of patients, and could potentially lead to a more specific diagnostic biomarker for treatment options. Full details can be found at Nature Cell biology
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