Saturday, July 18. 2009in News
Comments (0) | Trackbacks (0)
While several groups have shown abberant micro-RNA (or miRNA) expression in cancers, a group from Washington University Medical Centre have shown a direct-link of miRNA's as the primary course of a paediatric lung tumor. Pleuropulmonary blastoma (PPB) is an inherited cancer syndrome and the paper in Science by Hill et al. shows a link between the disease and families harbouring a heterozygous mutation in DICER1, the protein responsible for cleaving/processing miRNAs. They propose that loss of DICER1 expression in the epithelial tissue of the tumour alters proliferation of the surrounding mesenchymal tissue. This is the first paper showing a direct causal link between miRNA's and an associated cancer.
It is not unusual for the disease to be a result of a heterozygous mutation, as in the animal model a deletion of DICER1 is lethal due to the role miRNAs play during natural development. It is expected that DICER1 plays a similar in human development, and abberant DICER1 expression in a paediatric cancer is fitting with the hypothesised role for the protein.
DICER1 Mutations in Familial Pleuropulmonary Blastoma
New to ResearchGate?